
Advanced dynamic process control of a fluid-bed granulation process using PAT data improves product quality.
Chris O’Callaghan is senior product manager at Innopharma Technology, Dublin, Ireland, ocallaghanc@innopharmalabs.com.

Advanced dynamic process control of a fluid-bed granulation process using PAT data improves product quality.

A process control system based on PAT can compensate for variations in particle size, resulting in more consistent coating thickness in a Wurster coating process.

Process analytical technology, based on monitoring particle size distribution and tracking coating thickness measurements in real time, can be used to predict the dissolution of polymer-coated multiparticulates.

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