Shimadzu Scientific Instruments Inc.

Articles

This application demonstrates the efficiency, throughput, and reliability of a dual injection system for finished pharmaceutical products and in-process APIs.

Dual Injection (U)HPLC for Analysis of Pharmaceuticals

 is designed to push the limits of LC/MS/MS quantitation for applications requiring the highest sensitivity and robustness while delivering a meaningful solution for routine LC/MS/MS analyses. It detects substances at ultra-trace level as they occur in complex matrices, for example, or in smallest sample concentrations which have to be diluted in order to avoid matrix effects.

A real difference to working better and faster 

 is a member of Shimadzu’s UFMS (Ultra-Fast Mass Spectrometry) family and part of the Shimadzu mass spectrometry platform of MS/MS systems with ultra-fast technologies. It underlines Shimadzu’s role as one of the world’s fastest-growing mass spectrometry companies. The system combines a heated ESI source with all UF technologies including UFsweeper III, a collision cell filled with argon gas. Through its high speed technology, UFsweeper III achieves dwell times of 0.8 ms per MRM. With new UF Qarray ion guide technology increasing ion production and signal intensity, the LCMS-8060 introduces a new level of sensitivity and makes a real difference to working better and faster.

Highest sensitivity, fastest speed, outstanding durability

	With a data acquisition scan speed of 30,000 u/sec and a polarity switching time of
	5 msec the 

 brings new levels of data quality and confidence at the highest sensitivity.

 The newly developed UF-Qarray boosts ion sensitivity while suppressing noise. By improving the ion sampling device, ion guide and vacuum efficiency, Shimadzu has achieved an unprecedented sensitivity in LCMS.

 Shimadzu’s proprietary technologies allow acquisition of up to 555 MRM channels per second, ultra-fast polarity switching and ultra-fast scanning, all with highest data quality.

 Robustness of the LCMS-8060 and modified ion optics was assessed by injecting 2,400 samples of femtogram levels of alprazolam spiked into protein-precipitated human plasma extracts over a six day period (over 400 samples were injected each day). RSD of peak area response was 5 % over this test period, and use of a deuterated internal standard (alprazolam-d5) led to RSD of 3.5 %. As part of the robustness test the vacuum system was vented to model a transient power failure, with however no effect on signal response or baseline noise level.

Changes Everything  LCMS8060 triple quadrupole mass spectrometer expands UFMS family

 ultra high performance liquid chromatograph has become an indispensable tool in laboratories of versatile industries, such as pharmaceuticals, biochemistry, chemistry, environmental and foods. Users benefit from high-speed, high-resolution analysis without compromising robustness or reliability.

	The Nexera XR modular UHPLC system bridges the gap between the flexibility clients need and the reliability they want. The wide range of highly accurate and reliable modules provides the optimum system for analytical challenges in any field.

	On the safe side – with a pressure resistance of 660 bar, the 

 is a reliable all-round system, providing the superior performance of UHPLC with the robustness of a conventional HPLC system.

	The flexible choice – modular design allows configuration of tailor-made systems to meet specific application requirements. Each module delivers outstanding, reliable performance from HPLC to UHPLC application.

	The sensible option – the SPD-30AM multi-wavelength detector and RF-20Axs fluorescence detector offer unmatched performance. Equipped with unequalled optics and temperature control, these detectors achieve excellent sensitivity, baseline stability and reproducibility.