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Pharmaceutical Technology Europe-03-07-2011
Pharmaceutical Technology Europe
Direct Compression Versus Granulation
March 07, 2011
Special Feature
23
3
Compressed tablets are the most widely used solid dosage form so they must satisfy a number of physical requirements in terms of hardness, disintegration ability, friability and uniformity.
It's Goodbye From Me
March 07, 2011
23
3
This issue will mark the last issue for me as Editor of PTE. It's time for me to move on to pastures new and to say my goodbyes.
One-Pot Processing And The Benefits For Granulation
March 07, 2011
Special Feature
23
3
One-pot processing is a term that includes any technology that combines different unit operations of a pharmaceutical production process into one machine.
News
March 07, 2011
News
23
3
With the future of healthcare revolving more and more around patient empowerment, data and healthy outcomes, the big question is can the traditionally slow and reserved pharma industry keep up with the new era?
Calculating And Understanding Particulate Contamination Risk
March 07, 2011
Peer-Reviewed Research
23
3
The author presents a method to calculate the relationship between supply air volume flow and airborne particle concentrations.
Moisture-Activated Dry Granulation
March 07, 2011
Special Feature
23
3
Moisture Activated Dry Granulation (MADG) was developed in response to the difficulties experienced with wet granulation, in terms of endpoint, drying and milling. Wet granulation process endpoint is very sensitive to granulation time and shear. The wet granules need to be dried to a narrow range of moisture contents, which is difficult. The dried granules need to be milled, but the milled granules often have either too many fines or too many coarse particles (or both) - an undesirable bimodal distribution.
Drug Scandal Shocks France
March 07, 2011
Industry Insider
23
3
In France, public confidence in health authorities and pharmaceutical industry has been shaken by a safety scandal over the drug Mediator (benfluorex hydrochloride).
Establishing Endpoints
March 07, 2011
Special Feature
23
3
The unit selected for wet granulation, whether it be a high shear mixer or a fluidised bed, has a marked impact on granule properties.
Improving Solid Dosage Forms With Dry Granulation
March 07, 2011
Peer-Reviewed Research
23
3
Although tablet manufacture is traditionally a batchbased wet granulation process, there are many advantages to be gained by adopting dry granulation, including lower costs and increased yields.
The Benefits Of Tablet Tooling Standardisation
March 07, 2011
Manufacturing
23
3
Tooling standardisation in the tablet manufacturing industry is a topic that has concerned tabletting professionals for decades.
Magnetically Controlling Pills For Better Drug Delivery
March 02, 2011
Interview
23
3
Many solid oral dosage forms do not dissolve at the correct place in the gastrointestinal tract for them to be absorbed into the bloodstream. Could magnets solve the problem?
Using Particle Size Analysis To Track The Granulation Process
March 01, 2011
Special Feature
23
3
Use of in-process particle size analysis has enabled pharmaceutical scientists and process engineers to track the progress of a granulation process and detect its endpoint.
Pros And Cons Of Roll Compaction
March 01, 2011
Special Feature
23
3
There are two types of widely used dry granulation methods: slugging and roll compaction. Currently, roll compaction is preferred to slugging because it offers greater capacity and ease of process control.
In-Process Particle Characterisation
March 01, 2011
23
3
In wet granulation, many companies used to rely on empirical data and quality control, but processes and technologies have improved in a variety of ways in recent years.