The evaluation of the intrinsic dissolution rate of an active pharmaceutical ingredient can be used to demonstrate chemical purity and equivalency. The authors used a rotating disk system and a stationary disk system to determine the intrinsic dissolution rates of various model drugs.
Using formulations containing various types of lactose and dibasic calcium phosphate, the authors investigated the effects of lubricant level, lubrication time, and compression speed on tablet weight, hardness, and friability.
Transmucosal routes of drug delivery offer distinct advantages over peroral administration for systemic effect. The authors review buccal drug delivery and discuss the current status of buccal permeation enhancers.