Pharmaceutical Technology, April 2022

An early formulation strategy for tablets that is simple and scalable is recommended to ensure fewer downstream problems.

The author introduces a practical approach to determining the best estimate of probability for passing multiple stage dissolution tests.

Although not easy to do, it is essential because excipients can affect drug-product safety and efficacy.

Experts discuss what data to consider when selecting a high-potential drug candidate and how AI can be harnessed in medicinal chemistry drug discovery.

Collaboration and new tools aid efforts to implement new processing technologies for small-molecule drug product manufacturing.

Performing corrective action and preventive action (CAPA) activities is often necessary to investigate a manufacturing deviation and prevent it from reoccurring. Pharmaceutical Technology asked Joe O’Gorman, head of Global Operations at LZ Lifescience, a Cognizant Company, about the role technology plays in performing CAPAs.

Data may be used to improve (or remove) a corrective action/preventive action.

Effective cleaning and disinfection along with contamination controls are imperative when operating and utilizing a cleanroom.

The AMR Action Fund has made its first investments, marking an important step forward for the partnership to achieve its goal of bringing new treatments to the market for priority pathogens.

Pharmaceutical Technology spoke with Colleen Floreck, vice president, Global Marketing and Strategy, Catalent Cell and Gene Therapy about the specific requirements and challenges for expanding production of viral vectors.

The booming cell therapy market has created a need for capacity that outsourcing partners are ready to fill.

Meeting patient needs and achieving high quality are common goals for all stakeholders.

The continuous, aseptic fill/finish process is finding use in vaccines and biologic drugs.

In January 2022, Europe started to implement EU-CTR, a new regulatory framework for clinical trials, but what does this mean for pharma clinical research?

Innovations address supply-chain constraints, serialization, and new requirements for sustainable and patient-centric designs.

Quality metrics and more domestic production aim to avoid supply disruptions and drug shortages.

3D cell cultures could provide key avenues to unlocking critical information.

Experts Susan J. Schniepp, distinguished fellow for Regulatory Compliance Associates, and Steven J. Lynn, executive vice-president, Pharmaceuticals for Regulatory Compliance Associates, discuss the verification of compendial methods.

ROSS Batch High Shear Mixers are a versatile tool for powder delivery and dispersion of low-viscosity liquids.

The PureVessel series provides modular storage, preparation, treatment, and mixing of liquids.

The DynaPro NanoStar II introduces advanced walk-up capabilities in DLS technology.

Rockwell Automations newest graphic terminals increase user storage, product security, and support for modern peripherals.

Advances in pharmaceutical neuroscience present an opportunity for pharmaceutical companies to stay ahead of the curve.