The BIOSTAT STR single-use bioreactor family from Sartorius Stedim Biotech is based on a conventional stirred-tank design.
The BIOSTAT STR bioreactor family from Sartorius Stedim Biotech is a scalable, single-use bioreactor family based on a conventional stirred-tank design. The new bioreactor range includes upgraded hardware and software, as well as a fully integrated, new design of Flexsafe STR single-use bags. The bioreactor series, consisting of five systems in different sizes, offers working volumes from 12.5 L to 2000 L. Linear scale-up and process transfer from 250 mL to 2000 L can be achieved in weeks. The self-contained design of the new bioreactor with its single-use bag prevents product cross contamination, saving time in set-up, validation, clean-in-place procedures, and sterilize-in-place operations.
The system is designed for efficient oxygen transfer, mixing, and CO2 stripping. These combined features ensure cell culture performance with reproducible high-density growth of even sensitive cell lines. As a result, BIOSTAT STR bioreactors are suitable for achieving very high cell densities in continuous processes and for safe manufacture of vaccines and recombinant proteins in cGMP environments. Pictured is the BIOSTAT STR bioreactor in 500 L.