Bristol Myers Squibb Acquires Mirati Therapeutics for up to $5.8 Billion
Mirati’s focus on breakthrough cancer treatments will bolster Bristol Myers Squibb’s oncology portfolio.
TOP NEWS on grunge world map | Image Credit: © Sean K - stock.adobe.com
On Oct 8, 2023, Bristol Myers Squibb and Mirati Therapeutics announced that Bristol Myers Squibb has acquired Mirati for a total equity value of $4.8 billion. Mirati stockholders will receive one non-tradable Contingent Value Right for each Mirati share held, possibly representing another $1 billion. Both boards unanimously agreed on the merger.
Mirati is a commercial-stage targeted oncology company designed to create breakthrough therapies for cancer patients, making it a good fit with Bristol Myers Squibb’s oncology portfolio. One of Mirati’s most attractive assets, KRAZATI (adagrasib),is a lung cancer medicine that Bristol Myers Squibb will now add to its commercial portfolio. Adagrasib was given accelerated approval by FDA for the treatment of KRAS-mutated Non-Small Lung Cancer (NSCLC) in patients who have gone through one prior systemic therapy.
Other assets include MRTX1719, and a leading KRAS and KRAS enabling program. MRTX1719 is “a potential first-in-class MTA-cooperative PRMT5 inhibitor” currently in phase one development. It targets MTAP-deleted tumors, which make up around 10% of all cancers. The second phase of development is planned to start in the first half of 2024. The KRAS and KRAS enabling program include MRTX1133 and MRTX0902. MRTX113 targets the KRAS mutation, which contributes to key tumor types, and is implicated in over 30% of pancreatic cancer patients. MRTX0902 is a phase one SOS1 inhibitor that may have use in combination with other agents targeting the MAPK/RAS pathway, including Adagrasib.
“Mirati strengthens and complements our current portfolio by adding assets focused on intrinsic tumor targets in the MTAP and MAPK pathways,” said Samit Hirawat, M.D., Bristol Myers Squibb’s chief medical officer and head of Global Drug Development, in a press release. “We believe Mirati’s assets have the potential to change the standard of care in multiple cancers, both as standalone therapies and in combination with Bristol Myers Squibb’s existing pipeline. We are excited about the significant potential that this transaction creates to transform patients’ lives through science around the world.”
Source: Bristol Myers Squibb
Drug Solutions Podcast: A Closer Look at mRNA in Oncology and Vaccines
April 30th 2024In this episode fo the Drug Solutions Podcast, etherna’s vice-president of Technology and Innovation, Stefaan De Koker, discusses the merits and challenges of using mRNA as the foundation for therapeutics in oncology as well as for vaccines.
Drug Solutions Podcast: Gliding Through the Ins and Outs of the Pharma Supply Chain
November 14th 2023In this episode of the Drug Solutions podcast, Jill Murphy, former editor, speaks with Bourji Mourad, partnership director at ThermoSafe, about the supply chain in the pharmaceutical industry, specifically related to packaging, pharma air freight, and the pressure on suppliers with post-COVID-19 changes on delivery.
Shilpa Medicare Launches ‘Hybrid CDMO’ at DCAT Week 2025
March 17th 2025This model is being positioned by Shilpa as a dual approach that offers comprehensive discovery, clinical, and commercial outsourcing services in addition to commercially ready, “off-the-shelf” novel formulations for b2b licensing.
