PDA/FDA 2026 session maps the GMP audit lifecycle, root cause to CAPA closure, plus a local vs. above-site decision framework and two case studies.
|Articles|October 2, 2015
- Pharmaceutical Technology-10-02-2015
- Volume 38
- Issue 10
Microfluidics Systems Designed for Flow-Chemistry Experiments
The flexible Dolomite Flow Chemistry Systems from Dolomite Microfluidics can be configured to suit different applications.
The flexible Dolomite Flow Chemistry Systems from Dolomite Microfluidics can be configured to suit different applications. The systems can be used in education, continuous large-scale reactions, process optimization, scale-up, and multi-step reactions.
The Dolomite Flow Chemistry Systems are designed to provide control of residence time, reaction temperature, stoichiometry, and reagent introduction for performing detailed flow-chemistry experiments. The systems include a choice of glass microreactors or tube reactors in polytetrafluoroethylene or stainless steel from 2.5 µl up to 16 mL. The TCU-125 Temperature Controller ensures accurate temperature control of chips from 1 to 125 °C, and the tube reactors can be heated from room temperatures to 250 °C using a hotplate. The high performance and robust Mitos Duo syringe pumps ensure smooth flow rates, from 1.0 µl/min to 10 mL/min, and allow use of the two syringes independently or in one continuous flow, up to 6 bar. Standard systems can be upgraded for additional functionality, such as reaction automation, continuous work-up, small volume sample injection, or pressurized inputs.
Dolomite Microfluidics
Articles in this issue
almost 11 years ago
Identifying Powder Properties that Define Process Performancealmost 11 years ago
Connecting MES to Process Controlalmost 11 years ago
Parenteral Packaging Advancesalmost 11 years ago
Serialization Shake Outalmost 11 years ago
Investigating Biologicsalmost 11 years ago
Advances in Fluorination Chemistry for API Synthesisalmost 11 years ago
Small-Molecule API CMOs Are Thrivingalmost 11 years ago
Modular Platform for Agitator Bead Mill Optimizes Grindingalmost 11 years ago
Self-Contained Laboratory Homogenizer Prepares Injectable DrugsRelated to this article
The recently opened NJ spray drying facility doubles capacity for amorphous solid dispersions, addressing solubility limits in roughly 70% of small-molecule pipelines.
Lori Dingledine, QC Director Microbiological Control and GTIC Operations at Genentech, provided input on the regulations surrounding raw material manufacturing and use for ATMPs in a presentation at the 2026 PDA/FDA Joint Regulatory Conference.
AI can turn medical device risk management into a continuous signal.
Sanofi will transfer 20 mature medicines and three manufacturing sites to Cheplapharm for a 26.4% equity stake, closing by Q3 2027.
On PharmTech.com this week, coverage of upcoming events continued, experts continued to discuss the use of AI in pharma, and validation in oral solid dosage product production was emphasized.
Christy Owings, Thermo Fisher, on why early supply chain partnership and site visits prevent costly eCOA and clinical trial delays.
This article explores the historical use of silicone oil in the performance of primary drug product packaging; design of experiment test results for selection of the cleaning agent and CCPs; assessment of visible residue limits and Fourier-transform infrared spectroscopy surface analysis; and setting health-based exposure limits for silicone oil using a non-uniform distribution model, and a previously published permitted daily exposure.