New MALS Detector

April 2, 2019
Pharmaceutical Technology
Volume 43, Issue 4
Page Number: 12

Tosoh Bioscience’s LenS3 Multi-Angle Light Scattering (MALS) detector offers a new approach for measuring molecular weight (MW) and radius of gyration (Rg) of synthetic polymers, polysaccharides, proteins, and biopolymers.

Tosoh Bioscience’s LenS3Multi-Angle Light Scattering (MALS) detector offers a new approach for measuring molecular weight (MW) and radius of gyration (Rg) of synthetic polymers, polysaccharides, proteins, and biopolymers. The new detector has a new optical design, cell-block assembly, and calculation methodology. Featuring a patent-pending cell geometry and a lower wavelength laser (at 514 nm), the detector allows direct measurement of MW and provides high sensitivity. Additionally, with an improved normalization process and a new method for using the angular dependence, the determination of radius of gyration of smaller macromolecules below 10 nm in gyration size Rgis now possible, according to the company.

The instrument is supported by SECview software, which streamlines the calculations required by the advanced detectors and performs analysis of sample-of-interest using multiple calibration methods simultaneously. The software is capable of gel permeation chromatography system/hardware control, multi-channel data acquisition, data processing, and analysis.

Tosoh Bioscience

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