The work will focus on addressing a key bottleneck to progress: he complexity and instability of HIV envelope proteins, which has limited the amount of material that can be evaluated in clinical trials.
A $98-million, seven-year contract will fund work to improve manufacturing, at the International AIDS Vaccine Initiative
The US National Institutes of Health’s National Institute of Allergy and Infectious Diseases, has awarded the International AIDS Vaccine Initiative (IAVI) a $98-million, seven-year contract to help speed the development of AIDS vaccine candidates.
The contract covers a range of product development services to advance the characterization and manufacturing of HIV envelope protein immunogens, which has been a focus of IAVI’s research efforts.
Manufacturing of these immunogens has proven difficult, given the complexity and instability of HIV envelope proteins. This has limited the amount of material that can be evaluated in clinical trials. Optimizing HIV vaccine manufacturing would accelerate the development and evaluation of promising candidates.
IAVI and NIAID have been partnering closely in AIDS vaccine research for many years, including in the design and development of HIV envelope immunogens designed to trigger protective antibody responses.
Source: International AIDS Vaccine Initiative
Drug Solutions Podcast: A Closer Look at mRNA in Oncology and Vaccines
April 30th 2024In this episode fo the Drug Solutions Podcast, etherna’s vice-president of Technology and Innovation, Stefaan De Koker, discusses the merits and challenges of using mRNA as the foundation for therapeutics in oncology as well as for vaccines.
Understanding the Variability in Bioburden Test Results in Biomanufacturing
May 7th 2025This article explores the impact of test volume, microbial distribution, and dilution errors on bioburden testing variability. It presents statistical approaches to estimate percentage error and discusses strategies to optimize microbial enumeration techniques in biopharmaceutical quality control.
Drug Solutions Podcast: Gliding Through the Ins and Outs of the Pharma Supply Chain
November 14th 2023In this episode of the Drug Solutions podcast, Jill Murphy, former editor, speaks with Bourji Mourad, partnership director at ThermoSafe, about the supply chain in the pharmaceutical industry, specifically related to packaging, pharma air freight, and the pressure on suppliers with post-COVID-19 changes on delivery.
Intertek to Expand UK GMP Facility with 6000 Square Feet of Lab and Office Space
May 7th 2025The company said the expansion is in response to globally rising demand for inhaled biologics, which offer distinct advantages in route of administration, but can be challenging products for developers.