Polymer Influence on the Rheological Properties of Co-Processed Microcrystalline Cellulose and Sodium Carboxymethylcellulose

Peer-Reviewed

Submitted: May 14, 2021
Accepted: December 6, 2021

Abstract

Even time-tested pharmaceutical ingredients can falter if they are not paired with the right thickening and suspending agents, resulting in destabilized formulations. Similarly, achieving an effective final suspension, with optimal suspension viscosity and stability, depends on adding the right blend of polymers. In this study, researchers evaluated the colloidal microcrystalline cellulose (cMCC) suspending agent—a co-processed material of microcrystalline cellulose and sodium carboxymethyl cellulose (NaCMC)—by using a representative pharmaceutical-grade commercial version of cMCC. In addition to cMCC, water-soluble polymers are often added as thickening agents to enhance performance. Researchers evaluated commonly used water-soluble polymers, such as hydroxypropyl methylcellulose (HPMC), NaCMC, and povidone (PVP), as thickening agents in cMCC suspension formulations. cMCC suspensions were prepared with one of each thickening agent, in addition to one without a thickening agent, and studied for their rheological properties. Results showed a synergistic effect between HPMC and cMCC that increased the suspension’s viscosity and thixotropic property, leading to a stronger final gel-like network and suspending capability. However, adding PVP or NaCMC increased the initial viscosity but reduced the set-up suspension’s viscosity, which could indicate de-stabilization.

About the authors

Yeli Zhang is North America Technical Manager; Elizabeth Tocce is Associate Scientist; Holly Bertrand is Research Investigator; Kevin McIntyre is Laboratory Supervisor; Fernanda Onofre, Americas Regional Applications Leader; and Amina Faham is Global Director of Applications Development & Innovation; IFF Pharma Solutions, Wilmington, DE.

Article Details

Pharmaceutical Technology
Volume 46, Number 2
February 2022
Page: 40–44

Citation

When referring to this article, please cite it as Y. Zhang et al., “Polymer Influence on the Rheological Properties of Co-Processed Microcrystalline Cellulose and Sodium Carboxymethylcellulose,” Pharmaceutical Technology 46 (2) 2022.