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Colorcon Launches Acryl-EZE II to Extend pH Range of Enteric Coatings
The Acryl-EZE II works to extend Colorcon’s aqueous enteric systems by providing applications for tablets and multi-particulate dosage forms with increased enteric protection.
Colorcon announced on July 16, 2020 that it is launching the Acryl-EZE II to extend the pH range covered by its enteric coatings.
According to a company press release, the Acryl-EZE II works to extend Colorcon’s aqueous enteric systems by providing applications for tablets and multi-particulate dosage forms with increased enteric protection up to a level of pH 5.0 seen with patients taking PPIs, or when tested under fed conditions.
“This extension to the Acryl-EZE portfolio of products represents an advance in delayed-release coating technology to provide the pharmaceutical industry with added convenience for enteric coating,” said Kelly Boyer, general manager Film Coatings, Colorcon, in the press release. “Acryl-EZE formulations provide significant time savings in both development and production, while enabling targeted drug delivery across a wide pH range”.
“The formulation of enteric coatings is challenging; requiring multiple ingredients and process steps. Through Colorcon’s coating technology, this new Acryl-EZE II formulation provides simplified preparation and use, with enhanced protection up to pH 5.0 through the addition of a special top-coat,” added Dr. Ali Rajabi-Siahboomi, vice-president and chief scientific officer, Colorcon, in the press release. “Coating performance has been validated through a human volunteer study in the most challenging fed state conditions, confirming bioavailability and in-vivo performance.”
Source: Colorcon
