News

Article

Gore Releases New Fluoropolymer-Based mAb Purification Technology

Author(s):

The membrane-based Protein A purification tool was unveiled at the 2017 PepTalk Conference in San Diego, California.

Gore announced at the 2017 PepTalk meeting that it is introducing new technology for the purification of monoclonal antibodies (mAbs). The Protein A chromatography column uses an expanded polytetrafluoroethylene (ePTFE) membrane composite that is said to confer a binding capacity advantage at high flow rates and improve purification speeds.

Unlike resin-based columns made up of porous beads, the membrane from Gore is said to allow faster processing times because the device has a higher capacity with a shorter product residence time (srt). Gore estimates the the solids retention time for its technology is 20 srt vs. 60 srt for traditional agarose beads. The company says use of the membrane technology will allow for the elimination of a downstream concentration step during purification.

The membrane is chemically resistant and can withstand high temperatures, and therefore, several cleaning cycles.

Source: Gore

Newsletter

Get the essential updates shaping the future of pharma manufacturing and compliance—subscribe today to Pharmaceutical Technology and never miss a breakthrough.

Related Videos
A global supply chain map, visualizing the complex network of transportation routes and distribution centers | Image Credit: © venusvi - stock.adobe.com
Shortcut from point A to point B | Image Credit: © Olivier Le Moal - stock.adobe.com
Behind the Headlines, Episode 21: Waters-BD Merger, Merck’s $10B Bet, and Biotech’s Investment Frontiers
Wooden blocks spelling TARIFFS are placed on a map of North America, specifically over the United States and Mexico | Image Credit: © Rokas - stock.adobe.com
Jason Waite, International Trade Expert, Alston & Bird
Simona Guidi, Associate Director, ProPharma
Tore Bergsteiner
Behind the Headlines, Episode 20: CAR-T Milestones, Abbvie and Eli Lilly M&A Moves, and More
Related Content