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Pharmaceutical Technology

Pharmaceutical Technology-11-15-2018
Volume2018 eBook
Issue 2
Pages: 42–46

The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals

Author(s):

Eric Olson,Jonathon Salsbury

If a vortex mixer produces too much energy during sample preparation for particle size analysis, the size and morphology of particles can change. A study compares the applied shear to sample suspensions of ibuprofen to observe the effects of applied shear on the particle size distribution.

Sample preparation is a crucial step during particle size analysis, especially when trying to maximize accuracy and precision. A vortex mixer is frequently used its importance may be overlooked.

If a vortex mixer produces too much energy during sample preparation for particle size analysis, the size and morphology of particles can change. A study compares the applied shear to sample suspensions of ibuprofen to observe the effects of applied shear on the particle size distribution.

Read this article in Pharmaceutical Technology's Bio/Pharma Laboratory Best Practices 2018 eBook.

Article Details

Pharmaceutical Technology
ebook: Bio/Pharma Laboratory Best Practices 2018
Vol. 42
November 2018
Pages: 42–46

Citation

When referring to this article, please cite it as G. Maj, et al., "The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals," Pharmaceutical Technology Bio/Pharma Laboratory Best Practices eBook (November 2018).

Articles in this issue
Precompetitive Research Spurs Innovation in Pharmaceutical Analysis
Precompetitive Research Spurs Innovation in Pharmaceutical Analysis
Cobots in the Pharma Lab
Cobots in the Pharma Lab
Analytical Best Practices for Raw Materials Testing
Analytical Best Practices for Raw Materials Testing
Multiple Attributes Monitoring: A New Phase in PAT for Biopharmaceuticals
Multiple Attributes Monitoring: A New Phase in PAT for Biopharmaceuticals
Complex Protein Studies Demand Dynamic Techniques
Complex Protein Studies Demand Dynamic Techniques
The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals
The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals
Barriers and Solutions to Effective External Collaboration in Biopharma
Barriers and Solutions to Effective External Collaboration in Biopharma
Best Practices in Analytical Method Development and Testing
Best Practices in Analytical Method Development and Testing
Mixed Reality Gains a Foothold in the Lab
Mixed Reality Gains a Foothold in the Lab

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