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The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals
Eric Olson
Jonathon Salsbury
Jonathon Salsbury is an associate director at PPD GMP Lab, Middleton, WI.
Jeff Driscoll
Jeff Driscoll is an associate group leader at PPD GMP Lab, Middleton, WI.
Greg Maj
Greg Maj is a scientist at PPD GMP Lab, Middleton, WI.
If a vortex mixer produces too much energy during sample preparation for particle size analysis, the size and morphology of particles can change. A study compares the applied shear to sample suspensions of ibuprofen to observe the effects of applied shear on the particle size distribution.
Sample preparation is a crucial step during particle size analysis, especially when trying to maximize accuracy and precision. A vortex mixer is frequently used its importance may be overlooked.
If a vortex mixer produces too much energy during sample preparation for particle size analysis, the size and morphology of particles can change. A study compares the applied shear to sample suspensions of ibuprofen to observe the effects of applied shear on the particle size distribution.
Read this article in Pharmaceutical Technology's Bio/Pharma Laboratory Best Practices 2018 eBook.
Article Details
Pharmaceutical Technology
ebook: Bio/Pharma Laboratory Best Practices 2018
Vol. 42
November 2018
Pages: 42–46
Citation
When referring to this article, please cite it as G. Maj, et al., "The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals," Pharmaceutical Technology Bio/Pharma Laboratory Best Practices eBook (November 2018).