The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals

November 15, 2018
Eric Olson

,
Jonathon Salsbury

Jonathon Salsbury is an associate director at PPD GMP Lab, Middleton, WI.

,
Jeff Driscoll

Jeff Driscoll is an associate group leader at PPD GMP Lab, Middleton, WI.

,
Greg Maj

Greg Maj is a scientist at PPD GMP Lab, Middleton, WI.

Pharmaceutical Technology, Pharmaceutical Technology-11-15-2018, Volume 2018 eBook, Issue 2
Page Number: 42–46

If a vortex mixer produces too much energy during sample preparation for particle size analysis, the size and morphology of particles can change. A study compares the applied shear to sample suspensions of ibuprofen to observe the effects of applied shear on the particle size distribution.

Sample preparation is a crucial step during particle size analysis, especially when trying to maximize accuracy and precision. A vortex mixer is frequently used its importance may be overlooked.

If a vortex mixer produces too much energy during sample preparation for particle size analysis, the size and morphology of particles can change. A study compares the applied shear to sample suspensions of ibuprofen to observe the effects of applied shear on the particle size distribution.

Read this article in Pharmaceutical Technology's Bio/Pharma Laboratory Best Practices 2018 eBook.

Article Details

Pharmaceutical Technology
ebook: Bio/Pharma Laboratory Best Practices 2018
Vol. 42
November 2018
Pages: 42–46

Citation

When referring to this article, please cite it as G. Maj, et al., "The Impact of Vortexing on the Particle-Size Distribution of Pharmaceuticals," Pharmaceutical Technology Bio/Pharma Laboratory Best Practices eBook (November 2018).