Multiple Reaction Monitoring–Mass Spectrometry for Biopharmaceutical Analysis

G-Paolo Rizzardi;John McEntire;Cadnel Detchou;Simona Rovetta;Rowel Tobias;John Anders;Paola Belloni;

Multiple Reaction Monitoring–Mass Spectrometry for Biopharmaceutical Analysis

July 15, 2013

G-Paolo Rizzardi, John McEntire, Cadnel Detchou, Simona Rovetta, Rowel Tobias, John Anders, Paola Belloni

Pharmaceutical Technology, Pharmaceutical Technology-07-15-2013, Volume 2013 eBook, Issue 1

The authors describe two applications of a modified mass-spectrometry (MS) method, multiple reaction monitoring (MRM-MS), in biopharmaceutical analysis.

The authors describe two applications of a modified mass-spectrometry (MS) method, multiple reaction monitoring (MRM-MS), in biopharmaceutical analysis. The authors determined the relative abundance of process-related proteins and a specific residual impurity by use of an internally standardized MRM-MS technique for a recombinant fusion protein.

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