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Multiple Reaction Monitoring–Mass Spectrometry for Biopharmaceutical Analysis
G-Paolo Rizzardi, MolMed S.p.A
John McEntire, MolMed S.p.A
Cadnel Detchou, Analytical Bio-Chemistry Laboratories
Simona Rovetta, MolMed S.p.A
Rowel Tobias, Analytical Bio-Chemistry Laboratories
John Anders, Analytical Bio-Chemistry Laboratories
Paola Belloni, MolMed S.p.A
The authors describe two applications of a modified mass-spectrometry (MS) method, multiple reaction monitoring (MRM-MS), in biopharmaceutical analysis.
The authors describe two applications of a modified mass-spectrometry (MS) method, multiple reaction monitoring (MRM-MS), in biopharmaceutical analysis. The authors determined the relative abundance of process-related proteins and a specific residual impurity by use of an internally standardized MRM-MS technique for a recombinant fusion protein.
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