Top Use Cases and Applications for PROCIPIENT® Sterile

Sponsored by gChem

Dimethyl sulfoxide (DMSO) has long been used to protect cells during freezing and thawing. What has changed, according to Sandra Reid, senior director of sales at gChem, is the value of the cells being preserved. As cell and gene therapy (CGT), CAR T, and cell banking programs expand, manufacturers are placing greater emphasis on the quality of the materials used in their processes. This is driving interest in sterile DMSO, particularly in biopharmaceutical applications where purity, sterility, and documentation are essential.

CGT manufacturing already involves considerable biological variability. Manufacturers can help manage this variability by controlling raw material inputs. That means looking closely at supplier qualifications, sterility documentation, and change control procedures. Using a manufacturer-produced sterile DMSO, such as gChem's PROCIPIENT® Sterile, also eliminates the need for a separate sterilization step. This can reduce material handling and simplify the manufacturing workflow.

Sterile DMSO also has potential applications beyond cell therapy: parenteral drug delivery, long-acting injectables and suspensions. For scientists evaluating sterile DMSO, Reid recommends looking beyond the chemical itself. Key considerations include its compendial status and global registration, as well as sterility data for endotoxin, bioburden, and particulates. Equally important is the supplier's quality record, regulatory standing, documentation practices, technical expertise, and ability to maintain a reliable supply.