Pharmaceutical Technology-04-02-2010

Pharmaceutical Technology

Spherical Crystallization for Lean Solid-Dosage Manufacturing (Part II)

April 02, 2010

Peer-Reviewed Research

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In Part I of this article, which appeard in the March 2010 issue, the authors describe their approach for constructing form spaces for carbamazepine, cimetidine, and phenylbutazone by initial solvent screening to evaluate the feasibility of spherical crystallization. Part II of this article discusses their findings.

More Questions than Answers

April 02, 2010

Guest Editorial

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As the industry continues to evolve, do we know where we're headed?

Unconventional Communication

April 02, 2010

Agent-in Place

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Laboratory personnel share interesting tales as well as stories of unexpected tails.

The Effect of Overencapsulation on Disintegration and Dissolution

April 02, 2010

Peer-Reviewed Research

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The authors examined the disintegration and dissolution profiles of propranolol and rofecoxib tablets overencapsulated with standard hard-gelatin capsules and with capsules specifically designed for double-blind clinical trials.

Reduced-Method Robustness Testing of Analytical Methods Driven by a Risk-Based Approach

April 02, 2010

Peer-Reviewed Research

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The authors describe a novel approach for assessing method robustness. This article contains online-bonus material and was copublished with Pharmaceutical Technology Europe.

The Evolution of Single-Use Technologies in Aseptic Processing

April 02, 2010

Special Report

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The authors describe the origins of single-use components and explain their application to aseptic processes. They also show how disposable devices have changed over time and offer a glimpse of the future.

Pharmaceutical Technology, April 2010 Issue (PDF)

April 01, 2010

Issue PDF

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Spending More Or Less, And On What?