Development

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Articles

Plasma-based proteins and cell-based therapies have significant potential to address unmet medical needs.

Exploring the Therapeutic Value of Blood Components

Editor of Pharmaceutical Technology Europe

Rapid growth in biologics and increasing complexity of new compounds are some of the factors driving development of innovative delivery solutions.

Developments Driving Drug Delivery

Jennifer Putnam is AR&D supervisor II, Perrigo

Katherine L. Ullman is president, KLU Consulting, LLC

Priscilla Zawislak is global regulatory affairs advocacy manager, DuPont Nutrition & Biosciences

David Schoneker is president, Black Diamond Regulatory Consulting, LLC

George Collins is vice president, Vanderbilt Chemicals LLC. 

Douglas G. Muse is consultant—Compendial Affairs, Eli Lilly & Co.

Brian Carlin is director QbD/Regulatory, DFE Pharma US

Joseph Zeleznik is technical product manager, IMCD US

R. Christian Moreton, PhD, is vice-president of pharmaceutical sciences at Finnbrit Consulting and a member of Pharmaceutical Technology’s editorial advisory board.

Viewpoint: Continued dialogue among pharma stakeholders is needed to achieve consensus regarding excipient composition.


Understanding Concomitant Components in Pharmaceutical Excipients

The right partner can help companies overcome key formulation challenges for biologic drugs.

Overcoming Biologic Drug Formulation Hurdles

A newly developed polymer, DynaShield, may have the capability to ensure global access for COVID-19 treatment and prevention.

Helena Offers Polymer Solution to Global Cold Chain Issues for COVID-19 Vaccines, Biologics, and Therapeutics

Evonik offers lipid nanoparticles for gene-based drug development and manufacturing. 

Evonik Supplies Key LNP Technology for Gene-Based Drugs

A development agreement will study inhaled formulations of cannabinoid-based drug product for central nervous system diseases.

Kindeva and BOL Pharma to Develop Inhaled Cannabinoid Products

Operator, caregiver, and patient safety are at the forefront when selecting the best options and dosage forms.

HPAPI Complexity Prompts New Delivery Mechanisms

Supriya Bhide is a graduate student at the Department of Pharmaceutics and Drug Delivery, University of Mississippi, MS.

Apoorva Panda is a graduate student at the Department of Pharmaceutics and Drug Delivery, University of Mississippi, MS.

S. Rangappa is a research scientist at the Department of Pharmaceutics and Drug Delivery, University of Mississippi, MS.

Abhishek Shettar is a research scientist at the Department of Pharmaceutics and Drug Delivery, University of Mississippi, MS.

M.A. Repka is professor and chair at the Department of Pharmaceutics and Drug Delivery, University of Mississippi, MS.

Rosa Maria Badani Prado is a graduate student at the Dave C. Swalm School of Chemical Engineering, Mississippi State University, MS.

S. Kundu is associate professor at the Dave C. Swalm School of Chemical Engineering, Mississippi State University, MS.

Norman Richardson is technical sales manager at BASF Pharma Solutions, Florham Park, NJ.

S. Narasimha Murthy is professor of Pharmaceutics and Drug Delivery at the University of Mississippi, MS, founder-director of the Institute for Drug Delivery and Biomedical Research, Bangalore, Karnataka, India, and chief scientific officer, Topical Products Testing LLC, University, MS.

Study results indicate that fatty alcohols may plausibly enhance the skin permeation of clotrimazole.

Evaluating the Impact of Fatty Alcohols on Permeation of Clotrimazole from Topical Creams

At the 2020 Bio/Pharma Virtual Congress, experts discuss the importance of characterizing excipients to ensure quality, safety, and effective performance. 

Understanding Excipient Quality and Impact on Formulation

Nasser Nyamweya, PhD*, nasser04@yahoo.com, is a Director at Pharma Manufacturing Solutions. He was previously a Lecturer at the School of Pharmacy, University of Nairobi.

Samantha Kimani is a Pharmacist (B.Pharm) and recently graduated from the University of Nairobi.



This paper reviews considerations for the formulation of chewable tablets including sensory characteristics, chewability assessment, and drug release.

Chewable Tablets: A Review of Formulation Considerations

Amorphous solid dispersions are a useful tool in overcoming solubility issues, but they have not yet reached full potential in commercial success.

Improving Solubility with Amorphous Solid Dispersions

The IQ Consortium marks a decade of impactful innovation of collaboration through a network of pharmaceutical companies driving change for the bio/pharmaceutical industry.  

Viewpoint: Precompetitive Collaboration Drives Pharma Industry Innovation

More complex and challenging compounds require a more tailored approach to formulation strategies.

Unique Molecules Push Formulation Boundaries 

Taste-masking can be of significant importance in ensuring success of a drug product, particularly those targeted to pediatric or geriatric populations.

Masking Taste: A Key Attribute to Success

Excipients must be carefully chosen to ensure optimum protection for vaccines and live biotherapeutic products.

Factoring Stability in the Biologic Drug Mix

Tight development timelines and accelerated approval pathways favor simple, cost-effective capsule formulations.

Capsule Innovations: Speeding Up Drug Development

End-user considerations are becoming increasingly important as they can provide a lot of value and help to ensure commercial success of a drug.

Making the Ideal Dosage Form

Esra’a Albarahmieh is associate professor, Pharmaceutical Chemical Engineering department of the School of Applied Medical Sciences, German Jordanian University.

Mohammad Khanfar is associate professor, Pharmaceutical Chemical Engineering department of the School of Applied Medical Sciences, German Jordanian University.

Emad Alzubi is instructor and workshop manager at the Industrial Engineering department of the School of Applied Technical Sciences, German Jordanian University.

This study suggests that using a simple centrifugal method can produce a natural polymer-blend molecule that can successfully be used as an oral delivery mechanism for poorly soluble drugs. 

Fabrication Modulation of Zein-based Fibers for Oral Delivery of Hydrochlorothiazide

Particle engineering is a useful tool to manipulate API particles into a form that is manufacturable and deliverable to the patient.