Development

Articles

The IQ Consortium marks a decade of impactful innovation of collaboration through a network of pharmaceutical companies driving change for the bio/pharmaceutical industry.  

Viewpoint: Precompetitive Collaboration Drives Pharma Industry Innovation

Editor of Pharmaceutical Technology Europe

More complex and challenging compounds require a more tailored approach to formulation strategies.

Unique Molecules Push Formulation Boundaries 

Taste-masking can be of significant importance in ensuring success of a drug product, particularly those targeted to pediatric or geriatric populations.

Masking Taste: A Key Attribute to Success

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Excipients must be carefully chosen to ensure optimum protection for vaccines and live biotherapeutic products.

Factoring Stability in the Biologic Drug Mix

Tight development timelines and accelerated approval pathways favor simple, cost-effective capsule formulations.

Capsule Innovations: Speeding Up Drug Development

End-user considerations are becoming increasingly important as they can provide a lot of value and help to ensure commercial success of a drug.

Making the Ideal Dosage Form

Esra’a Albarahmieh is associate professor, Pharmaceutical Chemical Engineering department of the School of Applied Medical Sciences, German Jordanian University.

Mohammad Khanfar is associate professor, Pharmaceutical Chemical Engineering department of the School of Applied Medical Sciences, German Jordanian University.

Emad Alzubi is instructor and workshop manager at the Industrial Engineering department of the School of Applied Technical Sciences, German Jordanian University.

This study suggests that using a simple centrifugal method can produce a natural polymer-blend molecule that can successfully be used as an oral delivery mechanism for poorly soluble drugs. 

Fabrication Modulation of Zein-based Fibers for Oral Delivery of Hydrochlorothiazide

Particle engineering is a useful tool to manipulate API particles into a form that is manufacturable and deliverable to the patient.

A Great Manipulation: The Value of Engineering Particle Properties

Understanding and overcoming excipient variation are crucial for successful continuous processes.

Key Ingredients Needed to Drive the Success of Continuous Manufacturing 

The European Commission has approved Lynparza (olaparib) for use in patients with germline BRCA-mutated (gBRCAm) metastatic pancreatic cancer within the European Union.

European Commission Approves Lynparza for BRCA-Mutated Metastatic Pancreatic Cancer

Lonza is making additional investments in its global particle engineering network for expanded capacity and specialized capabilities.

Lonza Announces Additional Investments in Global Particle Engineering Services

The new facility in Grand Rapids, MI, is part of the CDMO’s aggressive expansion plan.

Grand River Aseptic Manufacturing Opens Large-Scale Injectable Fill/Finish Facility

Demand for custom drug delivery solutions is increasing and bringing forth an exciting period of valuable, innovative development opportunities.

Demand for Custom Dosage Forms Fuels Innovation

Controlled-release formulations offer numerous advantages for developers and patients, and this market is expected to continue to experience growth in the near future.

Taking a Controlled Approach

Increasing prevalence of drug misuse and abuse is driving a heightened and more stringent approach to abuse-deterrent formulations.

Reducing Risk with Abuse‑Deterrent Formulations

The authors compare formulations containing citrate with other buffers in reducing subcutaneous injection-site pain and discuss a formulation and excipients selection strategy.

Approaches to Alleviating Subcutaneous Injection-Site Pain for Citrate Formulations

In light of the hype around chloroquine and hydroxychloroquine as potential COVID-19 treatments, it is important to remember that drug repurposing should never be rushed, irrespective of the urgency of the situation.

Can We Teach an Old Drug New Tricks?

Many antibody-drug conjugate therapies are in the pipeline; however, only a handful have been approved. What are the bottlenecks? 

Formulating an ADC Development Solution

Reformulation strategies can provide drug developers with a head start to achieve promising options that benefit the patient.


A Welcome Change: The Benefits of Reformulation

With the acquisition, Orgenesis will combine TamirBio’s ranpirnase antiviral platform with its Bioxome technology.