Development

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Articles

Process control is essential for using continuous hot-melt extrusion to enhance solubility.

Continuous Hot-Melt Extrusion for Poorly Soluble APIs

Editor of Pharmaceutical Technology Europe

Podcasts

In this episode, Hanns-Christian Mahler and Andrea Allmendinger from ten23 health will discuss some key aspects of biologic drug development and manufacturing.

Drug Solutions Podcast: Considering Biologic Drug Development and Manufacturing Holistically

Unique solutions are required to protect inherently unstable messenger RNA.

Managing mRNA Instability

Despite the advantages intensified processes can offer developers, there are still some obstacles to overcome before broader application of new technologies will be implemented.

Formulating Drugs for Continuous Processing

Polyplus’ LipidBrick is designed to expand the scope of lipid nanoparticle formulation usage in mRNA therapeutics and vaccine development.

Polyplus Introduces Novel LNP Formulation for Use in mRNA Therapeutics

Feliza Mirasol is the science editor for 

Under a technology licensing agreement with Bhami Research Laboratory, Catalent intends to develop formulations that will allow for the delivery of high-concentration biologics subcutaneously.

Catalent Licenses Bhami Research Laboratory Technology for Biologics Formulation Development

Webcasts

ASDs by Spray Drying: Process Development & Scale-Up

Webinar Date/Time: Thu, Mar 30, 2023 11:00 AM EDT


Overcoming formulation challenges for mRNA and high-concentration proteins

Pramote Cholayudth previously was the managing director of the Professional Conference Center, Ltd. He currently is a validation consultant to Biolab Co., Ltd., in Thailand. He is the founder and manager of PM consult, cpramote2000@yahoo.com.

This article discusses the evaluation of paired content uniformity and weight variation data sets using F and T tests to ensure that batches meet compendial requirements.

Justification of Using Weight Variation Instead of Content Uniformity for Release of Relevant OSD Forms

Advancements in therapeutic modalities are necessitating change in drug delivery to help negate some of the expense of development and manufacturing.