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The newly installed Harro Hӧfliger encapsulation unit expands Capsugel’s clinical- and commercial-scale capacity for dry powder inhalation projects.
Capsugel has expanded its late-stage inhalation capabilities to advance dry powder inhalation (DPI) concepts through late-stage clinical trial and commercial production. A new Harro HÓ§fliger Modu-C MS encapsulation unit has been installed and validated at its Bend, Ore. facility that includes specialized drum-dosing technology for DPI development projects using spray-dry processing.
The equipment has an operational capacity of more than 72,000 capsules per hour. The technology provides 100% monitoring of dosed powder mass, fill weight ranges between 5 mg and 50 mg, and dose accuracy of <3% relative standard deviation.
The unit complements Capsugel’s Xcelodose 600S equipment that supports capsule filling for Phase 1 and Phase 2 trials. Capsugel’s capabilities for DPI formulations include spray drying for all clinical phases and commercial manufacturing, formulation development and scale-up, phase-appropriate encapsulation and full aerosol analytical capabilities in development and GMP.