Oral Protein Degrader Candidate Selector
Catalent’s ProteoSuite Oral platform is designed for optimized selection of orally developable targeted protein degrader candidates.
Catalent’s ProteoSuite Oral platform is designed for optimized selection of orally developable targeted protein degrader (TPD) candidates for advancement into clinical trials. Factors considered by the platform include molecular descriptors, physicochemical characterizations, drug metabolism and pharmacokinetics data, and physiologically based pharmacokinetic modeling.
The ProteoSuite aims to improve the likelihood of oral TPD development success by utilizing specialized assays and developability models that systematically evaluate oral drug candidates and enable quick, effective shortlisting of potential candidates. The platform includes integrated potent handling capabilities from clinical development and supply to commercial.
Drug Solutions Podcast: A Closer Look at mRNA in Oncology and Vaccines
April 30th 2024In this episode fo the Drug Solutions Podcast, etherna’s vice-president of Technology and Innovation, Stefaan De Koker, discusses the merits and challenges of using mRNA as the foundation for therapeutics in oncology as well as for vaccines.
Understanding the Variability in Bioburden Test Results in Biomanufacturing
May 7th 2025This article explores the impact of test volume, microbial distribution, and dilution errors on bioburden testing variability. It presents statistical approaches to estimate percentage error and discusses strategies to optimize microbial enumeration techniques in biopharmaceutical quality control.
