Manufacturing

Eric Sanchez is a senior consultant of Integra Continuous Manufacturing Systems with a special focus on the implementation of continuous manufacturing methods. He joined the firm after a successful 31-year career with Janssen Pharmaceuticals.

Fernando J. Muzzio, PhD, is distinguished professor of the School of Engineering at Rutgers, The State University of New Jersey, Piscataway, NJ 08855. Dr. Muzzio is a member of 

 editorial advisory board and President of Integra Continuous Manufacturing Systems.

Articles

Advanced manufacturing technologies are available, but challenges need to be addressed.

 Reshoring Pharmaceutical Manufacturing to the US: Can We Do It?

A contract from the US government will help fund domestic US production of small-molecule APIs and finished dosage forms and will be the first GMP facility using ICM technology.

Continuus to Build GMP End-to-End Continuous Manufacturing Facility

Jennifer Markarian is manufacturing editor of BioPharm International.

Early adopters and equipment manufacturers refine their equipment and processes, paving the way for broader use. 

Solid-Dose Continuous Manufacturing Presses On 

For certain APIs, including semi-synthetic antibiotics, continuous filtration and drying improves productivity and quality.

Considering Continuous Filtration and Drying

Experts at Hovione describe progress being made in understanding how to optimize continuous processes for oral solid-dosage drug products. 

Gaining Experience in Continuous Manufacturing

Cynthia A. Challener is a contributing editor to Pharmaceutical Technology.

Understanding and overcoming excipient variation are crucial for successful continuous processes.

Key Ingredients Needed to Drive the Success of Continuous Manufacturing 

Michael Thompson is a professor at McMaster University.

Kevin O’Donnell is R&D manager at DuPont Nutrition & Biosciences

Using a specific addition method to wet the powder bed in twin-screw granulation using a foam binder improves robustness for continuous solid-dosage drug product manufacturing.

Innovating Continuous Twin-Screw Granulation with Foam Delivery

Real-time monitoring and the principles of quality by design were used to optimize an OSD coating process.

Using Industry 4.0 to Optimize Oral Solid Dosage Form Manufacturing

The continuous manufacturing platform can be used for individual unit operations or a complete solid-dosage manufacturing line and can be integrated with third-party equipment.

Manufacturing, Continuous Solid Dosage Processing