Shimadzu’s New Q-TOF System Enhances Mass Spectrometry

Shimadzu’s new quadrupole time-of-flight (Q-TOF) LCMS-9030 system, a research-grade mass spectrometer, is designed to deliver-high resolution, accurate-mass detection with fast data acquisition rates. The new tool allows scientists to identify and quantify more compounds with greater confidence, according to the company.

The system utilizes the same engineering DNA from the company’s high-performance triple quadrupole (LC-MS/MS) platform, which is integrated with TOF architecture to achieve high-mass accuracy workflows with high-sensitivity, high-speed, and high-resolution detection.

The company unveiled its LCMS-9030 system at the 66th Annual American Society for Mass Spectrometry (ASMS) Conference on mass spectrometry and allied topics on June 3–7 in San Diego, CA.

Key technology drivers

Ultra-fast (UF) acquisition rates and core ion beam technologies developed for the triple quadrupole platform have created new possibilities in quantitative mass spectrometry by delivering high sensitivity, specific quantitation, and enhanced target compound verification, as stated by the company.

The new LCMS-9030 Q-TOF builds on this platform by rethinking time-of-flight detection. In the LCMS-9030, core ion beam technologies approach ion gating using UFaccumulation to create a precise pulse of ions into the flight tube, which has been optimized for high sensitivity and high resolution using iRefTOF reflectron technology. The iRefTOF generates a reflectron field, which delivers a high resolution for the flight path with highly stable mass accuracy, according to the company.

“Our Q-TOF technology on the LCMS-9030 will push the boundaries further for high mass accuracy and high mass resolution detection, and will make an impact across all applications, from small-molecule quantitation to complex intact protein analysis. This technology highlights Shimadzu’s passion for making something new and innovative as well as our commitment to making analysis better and promoting better science,” said Shuzo Maruyama, general manager, Analytical and Measuring Instruments Division, Shimadzu, in a company press release.

Source: Shimadzu