Thermo Fisher’s Newest Mass Spectrometry Innovations Deliver Better Performance

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Pharmaceutical Technology's In the Lab eNewsletter

In the Lab eNewsletter, Pharmaceutical Technology\'s In the Lab eNewsletter-07-03-2018, Volume 13, Issue 7

The company unveiled its latest innovations to its mass spectrometry portfolio at ASMS in San Diego.

Thermo Fisher Scientific’s newest innovations in its mass-spectrometry portfolio enhance scientists’ access to this technology across life sciences and applied markets. New instruments, accessories, and software deliver improved ease-of-use and higher performance that helps accelerate innovation and enhance productivity, as stated by the company.

The company unveiled its mass-spectrometry innovations at the 66th Annual American Society for Mass Spectrometry (ASMS) Conference that was held on June 3–7 at the San Diego Convention Center.

"From proteomic researchers who are discovering biomarkers of disease to forensics experts who are solving crimes, our customers need the capabilities and confidence to push scientific boundaries," said Dan Shine, president, analytical instruments, for Thermo Fisher, in a company press release. During ASMS, the company showcased how its expanded mass-spectrometry offering can help raise the bar in accuracy, sensitivity, and speed to achieve better results across a range of applications.

Improving small molecule characterization

The Thermo Scientific Orbitrap ID-X Tribrid Mass Spectrometer combines the company’s quadrupole, Orbitrap, and linear ion trap mass analyzer technologies, enabling users to acquire data with less experimental setup and interpretation expertise. The instruments support intelligent data acquisition and enhances scientists' interpretation of an unknown compound's mass spectra, according to the company. This system can also help reduce laboratory bottlenecks that limit the characterization, elucidation, and identification of small molecules across pharma/biopharma, metabolomics, and food safety applications.


The new Thermo Scientific Compound Discoverer 3.0 software detects pharmaceutical and food impurities, environmental contaminants, and novel metabolites that could improve disease diagnosis. It is also useful for screening controlled substances and related designer drugs. It includes a comprehensive, integrated set of libraries, databases, and statistical analysis tools that enable the complete characterization of small molecules using mass spectrometry.

Streamlining protein characterization

The Thermo Scientific Q Exactive UHMR Quadrupole Mass Spectrometer combines high-resolution, high-sensitivity mass spectrometry 2 (MS2) and pseudo-MS3 capabilities in a seamless workflow, which gives structural biologists and biopharmaceutical scientists access to an ultra-high mass range (UHMR) system for high-quality native mass spectrometry and top-down analysis.

A line of flush solutions, known as ChromaCare, and ultra-high-performance LC-MS (UHPLC-MS) solvents offer laboratories consistent access to interference-free separations and maximize instrument uptime. These new products help reduce background noise and prevent protein precipitation while increasing productivity across pharmaceutical, academic, environmental, and government laboratories.

Increasing quantitation confidence and speed

The Thermo Scientific TriPlus AutoSampler and Liquid Handling System with Robotic Tool Change delivers greater productivity and efficiency for laboratories by reducing time-consuming steps and increasing sample throughput. This technology offers the versatility of multistep workflows in a single, cost-effective solution. It can be fully customized to accommodate a range of sample processing needs in pharmaceutical, contract research, food safety, environmental, clinical research, and forensics applications.

Source: Thermo Fisher Scientific