Manufacturing

Near-infrared spectroscopy is a sophisticated and selective technique that has emerged as a powerful tool for the analysis of pharmaceuticals.

A knowledgeable and experienced contract service provider can help in the development and success of an inhalation drug product.

As the use of child-resistant packaging increases, efforts are underway to harmonize global standards and regulations.

The use of on-line auctions can provide increased business and new sellling opportunitites for suppliers.

Powdered self-emulsified dosage forms provide an attractive alternative to filled-capsule preparations, but the selection of a proper excipient is crucial.

In this study, the authors examine the suitability of 0.45 &#181m&#150rated filters to be used as sterilizing and bioburden-reduction filters against significant populations of organisms such as B. diminuta in a wide range of differential pressures.

Reverse auctions can benefit both buyers and suppliers of goods and services, but extensive preparation and careful management are required to obtain those benefits.

Adhesives manufacturers can be involved in the development of transdermal drug delivery products by working with pharmaceutical companies on R&D, materials qualification, manufacturing, and other product development tasks.

When FDA reviewed PDA's Technical Report No. 34 about isolator systems, significant differences of opinion between the organizations came to light.

Semisolid dosage forms are advantageous in terms of their easy application, rapid formulation, and ability to topically deliver a wide variety of drug molecules.

Low levels of some microorganisms that are present in oral solid dosage forms are unlikely to present a risk to patients. The amount of water activity in these products can help determine when microbiological testing should be conducted.

A limited number of container sizes, dispensing lanes, computerized tracking, and polyethylene mailing bags are just a few of the new elements of packaging launched at one company's automated pharmacy facility.

To achieve the maximum performance from a tablet press run, operators must learn to distinguish between machine-related issues and granulation-related issues.

Implementing an e-procurement solution requires executive sponsorship, up-front analysis of current processes, integration with back-end systems, and change mangement.

In the concluding part of this article, the authors address diffusive-airflow imprecisions and measurements as well as automated integrity-test equipment, variations in bubble-point measurements, and the identification of a "sterilizing" filter.

NIR quality control technology, relatively new to the pharmaceutical industry, could revolutionize processing and packaging.

Tablet manufacturers often overlook critical basic concepts or established practices. The author draws from his own experiences and discusses how solid dosage manufacturers can improve production and product quality by optimizing major unit operations.

The authors modified a three-layer press to operate a compression-coated tablet process that may offer several advantages over tradditional compression coating operations.

Manufacturers are gearing up to make labeling chnges required on most over&#173the&#173counter pharmaceutical products.

The author assesses the compressibility of Plasdone S- 630 copovidone-based tablet formulations using roller-compaction and direct-compression processes.

Both academia and industry have been encouraged to generate quick&#173dissolving dosage forms as the demand for fast&#173disintegrating tablets and capsules has steadily increased.

The latest developments in packaging technology made a strong showing at the 2001 Interphex exhibition.

Careful planning and decision-making can circumvent possible delays in technology transfers.

Significant advances have shaped the past 25 years in the pharmaceutical industry, and the next 25 years will be no exception.

Recent advances in pressurized metered-dose inhalers provide an optimistic outlook for the treatment of pulmonary and systemic diseases.

Appropriate sampling procedures, proper preparation, and correct instrumental parameters may yield differing, but correct, results.

In the past three decades, several industry-altering episodes have changed the face of pharmaceutical packaging.

Special considerations and cautions must be adhered to when designing virus safety studies and developing appropriate virus contamination control programs.

Cyclic olefin copolymer (COC) resins are showing a number of benefits that could propel their usage in syringe bodies, blister packs, and other packaging components.

Evolution of an existing drug molecule from a conventional form to a novel delivery system can significantly improve its performance in terms of patient compliance, safety, and efficacy. These days,drug delivery companies are engaged in the development of multiple platform technologies to get competitive advantage, extend patent life, and increase market share of their products.