Manufacturing, Solid and Semi-Solid Dosage Drugs

Aprecia and Glatt investigate manufacturing technologies to widen the formulation design space for oral delivery.

Intensified and distributed manufacturing approaches create flexible, local capacity.

Manufacturers of oral solid dose pharmaceutical formulations need PAT tools to reduce a product’s time-to-market and increase profitability.

Tests evaluated commercial rotary tablet presses to see how effectively they deal with problems such as poor flow, overlubrication, and capping.

Understanding difficulties that can occur during manufacture and resolving them quickly can improve oral solid-dosage drug production.

Aprecia's compression-free 3DP manufacturing platform and Glatt’s multiparticulate technologies offer solutions to pharmaceutical dosage design challenges.

Advanced manufacturing technologies are available, but challenges need to be addressed.

The new division will provide system solutions and individual machines and components.

The first of its kind, Lycagel is made up of pea starch technology.

The OneXpress solution is designed to accelerate oral dosage drug development and manufacturing.

CMDO Piramal Pharma Solutions held a grand opening at a facility they acquired in Sellersville, PA.

The renovations are expected to be completed by Feb. 1, 2021 and, upon completion, Aphena will move its corporate headquarters to the new location.

The $10 million expansion, which will be completed and fully operational by February 2021, will add on 3760 square feet of production space.

Early adopters and equipment manufacturers refine their equipment and processes, paving the way for broader use.

Data and software identify optimum pharmaceutical packaging choices for the required shelf-life.

Using a specific addition method to wet the powder bed in twin-screw granulation using a foam binder improves robustness for continuous solid-dosage drug product manufacturing.

Real-time monitoring and the principles of quality by design were used to optimize an OSD coating process.

The continuous manufacturing platform can be used for individual unit operations or a complete solid-dosage manufacturing line and can be integrated with third-party equipment.

The facility has dedicated manufacturing and packaging for oral solid dosage forms, liquids, creams, and ointments.

Under the terms of the agreement, Catalent will develop a powder-in-capsule formulation of Ennaid’s ENU200 program at its site in San Diego, CA.

Supplier of punches and dies to tablet producers, I Holland, has reported that it will be revisiting its webinar series, investigating best practices in tablet manufacture, for those currently working from home.

A quick look at the history of OTC dosage form development shows the importance of patient-centered innovation.

Risk levels should be considered when designing containment for pharmaceutical tableting equipment to enhance operator safety.

Understanding formulation properties early in development can prevent some costly issues later on.

OSD forms are popular within the industry due to the various advantages they offer, but there are specific considerations required to get the best OSD form possible.

This article examines multi-tip tool technology for pharmaceutical tablet compression and the process control and validation issues that must be carefully evaluated to assess the potential for success.

Tools help improve understanding of excipient risk in formulating OSD drugs.

This paper discusses what causes cross-linking, how cross-linking is addressed with addition of enzymes, and consideration for occasional high results that can be obtained during release testing.

Advanced dynamic process control of a fluid-bed granulation process using PAT data improves product quality.

A coalition establishes a secure, direct link between a physical tablet and a digital backend for supply chain integrity.