Manufacturing, Solid and Semi-Solid Dosage Drugs

This paper describes how the concept of acceptance value can be redefined to remove bias and more closely reflect quality targets.

The company’s planned investment in its alkoxylation facility in the United States Gulf Coast will also expand production capacity for its polyethylene glycols.

At CPhI Worldwide 2018, Tom Wilson, vice president of Contract Manufacturing Operations for Pfizer Global Supply and Pfizer CentreOne Contract Manufacturing, will discuss best practices for meeting manufacturing challenges of compliance as requirements shift.

Innovative technologies, such as drug-loaded devices and 3D printing, enable advances in implantable devices and other novel dosage forms.

Barrier materials, scavengers, and good seal integrity maximize shelf-life of oral solid-dosage drug packaging.

A twin-screw extruder can be used as a continuous wet granulator.

Engineering controls and safe practices for containment protect both operator and product in tablet and capsule production.

3D printing is being explored as a manufacturing method for on-demand, personalized medicine.

Coperion’s ZSK 18 MEGAlab extruder fulfills requirements for both wet extrusion and hot-melt extrusion pharmaceutical processes.

API-in-capsule approaches enable pharmaceutical companies to quickly assess new drug candidates with reduced API consumption and to increase speed to clinic.

A twin-screw extruder can be used as a continuous wet granulator or as a continuous mixer for a wet gelatin mass.

A process control system based on PAT can compensate for variations in particle size, resulting in more consistent coating thickness in a Wurster coating process.

Jean-Yves Balfin, product manager at Korsch AG, speaks to Pharmaceutical Technology about the ins and outs of multilayer tableting.

Increasing dwell time can improve tablet production.

Certain blister card packages that do not meet US child-resistant packaging requirements are being recalled because they pose a risk of harm if the tablets are swallowed by children.

Bosch Packaging Technology’s GKF 720 capsule filling machine for small batches of hard capsules uses a fully automated, washable containment process.

The acquisition expands Micromeritics’ portfolio of products and solutions.

Bosch Packaging Technology will introduce its newest R&D device for continuous oral solid dosage production at Achema 2018.

The UK’s University of Sheffield opened a new chemical engineering teaching plant for continuous oral solid-dosage pharmaceuticals using GEA’s multipurpose platform.

Glatt Ingenieurtechnik has added compact continuous agglomeration equipment and new control systems to its "modular plant engineering" portfolio.

GEA and Perceptive Engineering will collaborate to promote and deploy multivariate monitoring and advanced process control (APC) solutions for batch and continuous pharmaceutical process units.

Netzsch will present a new compact grinding/separating system, LabCompactPlus, for chemical, pharmaceutical, and cosmetic laboratories at Achema 2018.

As more continuous processes move toward commercialization, users and equipment vendors are working to speed changeovers and address other needs.

Bosch’s Industry 4.0 solutions deliver full transparency for all process and machine data.

Romaco will display the IHD series for processing hot melt coatings at Achema 2018.