Manufacturing, Solid and Semi-Solid Dosage Drugs

Although the source of spots and specks on tablets is sometimes difficult to identify, following good maintenance and manufacturing practices can help solve or even prevent the problem.

As the second part of this series, we look at the importance of ?assessing? the punches and dies to check their condition and how this step may help avoid any problems that may occur during tablet manufacture.

Capsugel gives lead users access to intrinsically enteric capsule technology and support services.

A G-CON, GEA, and Pfizer collaboration developed a PCMM (portable, continuous, miniature, and modular) system to produce oral solid-dosage drugs.

This review highlights relevant physicochemical drug properties and formulation design considerations critical to quality and performance of the sublingual tablets.

Many factors can contribute to tablet manufacturing problems. Tablet tooling failures are generally the result of one, or a combination of issues.

PharmaSpray delivers a consistent, validatable amount of dry lubricant.

Fette Compacting America FE75 Tablet Press is designed to produce up to 1.6 million tablets per hour.

I Holland, in collaboration with the University of Nottingham and experts from the Laboratory of Biophysics and Surface Analysis, United Kingdom, recently completed a two-year tableting science anti-stick research (TSAR) project, which sought to understand why certain formulations stick to tablet tooling.

Leading global tablet tooling manufacturer, I Holland has a range of multiple tip punches and dies optimised to meet the requirements of modern tablet production.

Molecular Profiles has expanded its capsule filling capability following significant investment into new equipment at its clinical manufacturing site in the United Kingdom.

FDA approved XTANDI for the treatment of metastatic castration-resistant prostate cancer.

Conventional tablets may no longer be the go-to solution.

Study provides first substantive reference data on key quality attributes of empty capsules

American Health Packaging announced a voluntary nationwide recall of ibuprofen and oxcarbazepine tablets due to mislabeling on the inner unit dose blister packaging.

Fette's FE75 Tablet Press is designed for large batches.

Progress in equipment availability, process analytical technology, and advanced process control aids ongoing development of continuous solid-dosage manufacturing processes.

The Manesty TPR 500 tablet press from Bosch Packaging Technology increases output and features a hygienic design.

Doug Hausner, Engineering Research Center for Structured Organic Particulate Systems, Rutgers University discusses continuous manufacturing for solid-dosage drug production.

The author discusses various aspects of the hot-melt extrusion process and outlines a practical approach to scale-up.

The authors describe how modular systems can be applied to continuous solid-dosage and nutraceutical manufacturing.

Charlie Martin, Leistritz Extrusion, describes hot-melt extrusion manufacturing processes and advances.

The author examines the effect of compaction force, gap width, and sieve setup on granule size.

The selection of excipients is important in generic formulations due to the impact it has on the risk and performance of generic drugs.

Catalent Pharma Solutions recently launched several new softgel product developments, all of which solve a delivery problem, while offering IP advantages to drug manufacturers.