When splitting unscored tablets, the main concerns relate to API dosage control and the potential modification of time-release characteristics. PTE speaks with tableting experts Thierry Menard, Lab Manager, And Bruno Villa, President, both at Medelpharm, about how manufacturers are approaching the challenges.
Tablet splitting is a new area of focus for regulators. The FDA tells PTE more about the challenges in this area.
GlaxoSmithKline recently developed a novel technology for the formulation of modified-release tablets. The authors describe the route from development to commercialization.
Particle-engineering technologies, such as crystal design for crystallization and producting cocrystals, particle-size reduction, and amorphous solid dispersions, help to optimize delivery of a drug.
Particle-engineering technologies, such as crystal design for crystallization and producting cocrystals, particle-size reduction, and amorphous solid dispersions, help to optimize delivery of a drug.
Fluid-Bag Ltd provides comprehensive 900 and 1000 litre flexible IBC systems for liquid and semi-solid products, including filling and discharging equipment. The GMP compliant container system is designed to guarantee uniform liquid, maximise payload and minimise discharge residue (0.5% residue).
This study examines the effect and interaction of variations in hypromellose physicochemical properties.
The physical form of an API is an important consideration in formulation development. Particle-engineering technologies, such as crystal design for controlling crystallisation and producing cocrystals, particle-size reduction and amorphous solid dispersions, help to optimise delivery of a drug.
The advantages and disadvantages of hot-melt extrusion in solid dispersion formulations.
The authors investigate the tablet-coating process using a combination of different simulation techniques.
The authors describe a solid form technology platform used to optimize salt selection, cocrystallization identification and modification, or the development of a free form.
Rob Blanchard and Clive Roberts discuss the issues surrounding tablet sticking.
Industry experts share their insight on solid-dosage and sterile manufacturing.
Developments in hot-melt extrusion using twin-screw extruders to make solid-dosage drug forms.
In addition to the established coating systems (like the BFC and the BFC TriPan), Bohle developed a new coater to face the market needs, the Bohle-Tablet-Coater BTC.
New coating technologies achieve high uniformity and reduce waste through mixing system advances and pan and airflow configuration.
Advances in process analytical technology and in defining lots for release are key for enabling use of continuous processes in solid-dosage manufacturing.
A technical forum featuring Tim Freeman of Freeman Technology and Carl Levoguer of Malvern Instruments.
As part of an ongoing collaboration into tabletting science, I Holland and the UK's University of Nottingham have launched a two-year programme to investigate the cause of tabletting sticking.
In our tablet coating process, we are losing up to 15% of our coating solution in each processing run. What can we do to prevent this problem in order to reduce waste and increase our cost efficiency?
CML - Solid State Chemistry
The article examines some recent developments for this process step and for continuous manufacturing overall.
This article considers the different conditions to which the powder is subjected in the tableting process, and discusses which powder properties should be measured to accurately reflect likely powder behavior in the process.
Taste-masking is an important consideration to ensure patient compliance.
Experts in solid dosage discuss the formulation and manufacture of multilayer tablets.
