High quality tablet compression tooling is expensive, albeit consumable. With the potential for tooling damage during tablet production, transportation and storage, an acceptable method of cleaning, repairing, validating and storing tooling is required by anyone who manufactures tablets - and the regulatory inspection authorities.
Decision-making tools such as expert systems and artificial neural networks can be integrated to facilitate the development of optimal formulations of hard gelatin capsules.
Spreadability of a semisolid forrmulation is affected by factors such as formulation characteristics, rate and time of shear, temperature, site of application, and the presence of various additives.
Dynamic powder-sampling methods may be the best techniques for obtaining a representative sample for determining particle-size distribution.
Powdered self-emulsified dosage forms provide an attractive alternative to filled-capsule preparations, but the selection of a proper excipient is crucial.
Semisolid dosage forms are advantageous in terms of their easy application, rapid formulation, and ability to topically deliver a wide variety of drug molecules.
The delivery agent-mediated transport of low moleular weight heparin across Caco-2 cells is accomplished without opening the junctions or adversely affecting the structural integrity of the cell monolayer.
Low levels of some microorganisms that are present in oral solid dosage forms are unlikely to present a risk to patients. The amount of water activity in these products can help determine when microbiological testing should be conducted.
To achieve the maximum performance from a tablet press run, operators must learn to distinguish between machine-related issues and granulation-related issues.
Tablet manufacturers often overlook critical basic concepts or established practices. The author draws from his own experiences and discusses how solid dosage manufacturers can improve production and product quality by optimizing major unit operations.
The authors modified a three-layer press to operate a compression-coated tablet process that may offer several advantages over tradditional compression coating operations.
The author assesses the compressibility of Plasdone S- 630 copovidone-based tablet formulations using roller-compaction and direct-compression processes.
This comparative study suggests that pregelatinized starches are superior to natural starches in terms of improving the plastic deformation in tablet formulations during compression.
This study attempts to determine the combination of excipients found in commercial ASA products that would be suitable for use in an aqueous enteric film­coating process.
Both academia and industry have been encouraged to generate quick­dissolving dosage forms as the demand for fast­disintegrating tablets and capsules has steadily increased.
Appropriate sampling procedures, proper preparation, and correct instrumental parameters may yield differing, but correct, results.
Evolution of an existing drug molecule from a conventional form to a novel delivery system can significantly improve its performance in terms of patient compliance, safety, and efficacy. These days,drug delivery companies are engaged in the development of multiple platform technologies to get competitive advantage, extend patent life, and increase market share of their products.
