Solid/Semi-Solid Dosage

FDA funded projects at Rutgers' C-SOPS and at UMass Lowell to develop flow-sheet model algorithms for use in risk assessment, and start-up company Continuus Pharmaceuticals is making progress on their integrated system.

The final article of this series will look at the last two steps of the PharmaCare seven-step process?Lubricate and Store.

Solving the problem of tablet spots or specks involves prevention and thorough investigation.

Dr. Thomas Hein, Director Business Development and Regulatory Affairs at Hermes Pharma, discusses the difference between user-friendly dosage forms and conventional tablets and capsules.

A good cleaning regime goes hand in hand with a good polishing regime, which forms Step 5 of the process and is arguably the next most critical step. It is cleaning and polishing that deliver most noticeable benefit into production, reducing tablet press down time and helping to increase productivity.

Aurobindo Pharma USA issued a voluntary nationwide recall of Northstar Label Gabapentin Capsules, USP 300 mg, due to complaints of empty capsules.

Over the last three weeks, we have been looking at each step and the benefit of adopting the process. This week, we look at Step 4, Measure.

Although the source of spots and specks on tablets is sometimes difficult to identify, following good maintenance and manufacturing practices can help solve or even prevent the problem.

Carrying on from our weekly column to help you eliminate a number of tablet manufacturing problems and tablet tooling failures with a simple seven-step tool-care process, we look at the third step, Repair.

As the second part of this series, we look at the importance of ?assessing? the punches and dies to check their condition and how this step may help avoid any problems that may occur during tablet manufacture.

Capsugel gives lead users access to intrinsically enteric capsule technology and support services.

A G-CON, GEA, and Pfizer collaboration developed a PCMM (portable, continuous, miniature, and modular) system to produce oral solid-dosage drugs.

This review highlights relevant physicochemical drug properties and formulation design considerations critical to quality and performance of the sublingual tablets.

Many factors can contribute to tablet manufacturing problems. Tablet tooling failures are generally the result of one, or a combination of issues.

Contract Packaging Resources issued a voluntary recall of naproxen sodium tablets because some cartons contain bottles of ibuprofen.

PharmaSpray delivers a consistent, validatable amount of dry lubricant.

The last 12 months have seen a number of major acquisitions in the contract manufacturing space.

Romaco Kilian's KTP 420X tablet press compresses up to 360,000 tablets an hour.

Fette Compacting America FE75 Tablet Press is designed to produce up to 1.6 million tablets per hour.

Weighing the pros and cons of hot-melt extrusion and spray drying.

I Holland, in collaboration with the University of Nottingham and experts from the Laboratory of Biophysics and Surface Analysis, United Kingdom, recently completed a two-year tableting science anti-stick research (TSAR) project, which sought to understand why certain formulations stick to tablet tooling.

Leading global tablet tooling manufacturer, I Holland has a range of multiple tip punches and dies optimised to meet the requirements of modern tablet production.

Molecular Profiles has expanded its capsule filling capability following significant investment into new equipment at its clinical manufacturing site in the United Kingdom.

FDA approved XTANDI for the treatment of metastatic castration-resistant prostate cancer.

Conventional tablets may no longer be the go-to solution.

Tool coatings are now seen as an acceptable means of solving production problems, such as sticking and corrosion, resulting in increased product yield.

Efforts to tackle challenges in tablet manufacture are shaped by quality by design (QbD) and continuous manufacturing.

Stephen Tindal from Catalent Pharma Solutions speaks with Pharmaceutical Technology Europe about advances in softgel technologies.

Softgels are now being recognised as one of the preferred dosage forms for the treatment of pain, eye conditions, cough and cold, as well as allergy.